|
KMID : 1143420200130473348
|
|
Public Health Weekly Report
2020 Volume.13 No. 47 p.3348 ~ p.3355
|
|
|
Distributions of carbapenem-resistant Enterobacteriaceae (CRE) in Korea, 2019
|
|
Go Eun-Byeul
Joo Seong-Jae
Hwang Kyu-Jam
Park Sung-Do
|
|
|
Abstract
|
|
|
The occrrence of carbapenem-resistant Enterobacteriaceae (CRE), a major healthcare-related infectious disease, is rapidly increasing not only in Korea but also around the world. Carbapenemase is a primary mechanism of resistance to carbapenems. carbapenems cause the spread of carbapenem resistance by horizontal gene transfer. Currently, the most common type of CRE is the Klebsiella pneumoniae, because of its ability to easily coloniz and spread quickly in hospital environments. Also, the most commonly identified carbapenemase gene in Korea is Klebsiella pneumoniae carbapenemase (KPC) type, Research indicates that it is harbored by Klebsiella pneumoniae
In accordance with the revision of the Infectious Disease Prevention and Management Act, CRE was designated as a second-class infectious disease in 2020. A total of 8,333 CRE isolates from Research Institute of Public Health and the Environment (RIPHE) were analyzed. The RIPHE analyzed distribution of strains, trends in carabapenem resistantce, and their carbapenemase gene types. A significant number of the CRE strains were Klebsiella pneumoniae (59.9%) and Escherichia coli (19.4%). The resistant rate for each carbapenem was ertapenem (99.4%), meropenem (70.0%), imipenem (73.2%) and doripenem (55.8%), respectively. Among these isolates, 74.4% of the CRE strains harbored carbapenemase genes. The predominant carbapenemase-producing Enterobacteriaceae (CPE) strain types were KPC-2 (78.2%), NDM-1 (9.4%), NDM-5 (5.4%), and NDM-5/OXA-181 (5.4%).
This study presented the prevalent species of CRE and CPE genotypes of 2019 in Korea. This study recommended that the results be used to control and prevent infectious diseases in Korea through continuous monitoring.
|
|
|
KEYWORD
|
|
|
Cabapenem-resistant Enterobacteriaceae, Carbapenemase-producing Enterobacteriaceae, Klebsiella pneumoniae, KPC-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|